How we attach meaning to events in our lives has a large influence on the quality of our life.
Imagine, for example, that a friend fails to show up to a lunch date. You have choices as to what you will make this experience mean for you. You could allow being "stood up" to reinforce your feelings of unworthiness, you could begin to mentally attack your friend's character, or you could assume that something big must have happened to cause them to miss the date--then, you might open yourself up to enjoying some relaxing time alone.
If you were recently laid off and are having difficulty finding a new job, consider that you might have hidden gifts or passions that were untapped in your regular career that you are now available to explore. The universe might simply be moving you in a more fulfilling direction. If you have recently lost a loved one, gained weight, lost money, or gotten in a fight with your partner, see if you can infuse the experience with meaning that feels loving and empowering and opens a door for you to embrace life and the world a bit more.
When we begin to bring consciousness to what we are making things mean, we may be shocked at the messages we have been feeding ourselves all these years. Try taking the reins and begin assigning a kinder meaning to the events in your life and you will likely find yourself on a much more pleasant ride.