Increased Metabolic Rate May Lead to Accelerated Aging

Findings from new study may explain why low-calorie diets are beneficial for human health

Newswise — Chevy Chase, MD— A recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM) found that higher metabolic rates predict early natural mortality, indicating that higher energy turnover may accelerate aging in humans.

Higher energy turnover is associated with shorter lifespan in animals, but evidence for this association in humans is limited. To investigate whether higher metabolic rate is associated with aging in humans, this study examined whether energy expenditure, measured in a metabolic chamber over 24 hours and during rest predicts natural mortality.

“We found that higher endogenous metabolic rate, that is how much energy the body uses for normal body functions, is a risk factor for earlier mortality,” said Reiner Jumpertz, MD, of the National Institute of Diabetes and Digestive and Kidney Diseases in Phoenix, Ariz., and lead author of the study. “This increased metabolic rate may lead to earlier organ damage (in effect accelerated aging) possibly by accumulation of toxic substances produced with the increase in energy turnover.”

“It is important to note that these data do not apply to exercise-related energy expenditure,” added Jumpertz. “This activity clearly has beneficial effects on human health.”

In this study, researchers evaluated 652 non-diabetic healthy Pima Indian volunteers. Twenty four hour energy expenditure (24EE) was measured in 508 individuals, resting metabolic rate (RMR) was measured in 384 individuals and 240 underwent both measurements on separate days. Data for 24EE were collected in a respiratory chamber between 1985 and 2006 with a mean follow-up time of 11.1 years. RMR was evaluated using an open-circuit respiratory hood system between 1982 and 2006 with a mean follow-up time of 15.4 years.

During the study period, 27 study participants died of natural causes. Researchers found that as energy expenditure increased, there was also an increase in risk for natural mortality.

“The results of this study may help us understand some of the underlying mechanisms of human aging and indicate why reductions in metabolic rate, for instance via low calorie diets, appear to be beneficial for human health,” said Jumpertz.

Other researchers working on the study include: Robert Hanson, Maurice Sievers, Peter Bennett, Robert Nelson and Jonathan Krakoff of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, in Phoenix, Ariz.

The article, “Higher energy expenditure in humans predicts natural mortality,” appears in the June 2011 issue of JCEM. 

Founded in 1916, The Endocrine Society is the world’s oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology. Today, The Endocrine Society’s membership consists of over 14,000 scientists, physicians, educators, nurses and students in more than 100 countries. Society members represent all basic, applied and clinical interests in endocrinology. The Endocrine Society is based in Chevy Chase, Maryland. To learn more about the Society and the field of endocrinology, visit our site at www.endo-society.org.

WOD's

Workout #1
AMRAP 15 minutes
5 squat snatch
10 knees to elbows
10 push ups


Workout #2
Run1000m
5 rounds of:
10 pull ups
10 deadlifts
Row 1000m


Workout #3
1 minute of work at each station followed by 1 minute of rest after each effort
Box jumps
Pull ups
Air squats
Push ups
V-ups

The Biological Passport Part 2: Effective fight or futile failure?

So last week I had a first look at some of the science of the biological passport,and specifically the legal aspects of how that science is interpreted.  Thanks for the great discussion to that post, and especially from those who "dropped by" to share some insights from the passport team itself!  As is often the case (always, maybe), your discussion is twice as good as the original post!

Also, I'm unashamed to admit that on this particular topic, I can't even deliver satisfactory answers to many of your questions!  It's clearly a mighty complex topic, and one that discussion will help grow understanding of.

So today, we forge ahead with what I ended off on, and that it is the question ofwhether the passport is worth the effort, or whether the cyclists are able to "dodge" it so effectively that it's just another attempt by the doping control to catch the dopers from behind.

The origin of this debate come from many sources.  There is certainly a perception, or a swell of opinion, that because the passport sets such stringent limits, it "misses" or fails to detect when doping has occurred.  People point to the lack of convictions as proof of its ineffectiveness.  Hopefully, in that last post, I was able to explain or introduce why this very strict probability limit is applied.  Before we can continue, I must recap very briefly (I won't repeat that mammoth post, don't panic!):

CrossFit Chronicles: Is it time to consider a special diet?

Posted: Thursday, April 21, 2011 10:01 am | Updated: 11:59 am, Thu Apr 21, 2011.

By Jen Wielgus |

I've never been one to buy into a specific "name" diet plan. They all seem like fads to me -- not to mention a big hassle -- and while I've always tried to watch what I put in my mouth and get proper nutrition, I didn't want some program telling me what to eat every day. I wanted to keep my options open, and not have to think too much about what was or wasn't on the plan.

Staying in control was going to be a problem for me, whether I was "on a diet" or not. And I'm not going to lie, there are times I enjoy losing control. Don't we all have those moments?

Two things have changed my perspective on diets: A certain digestive affliction I've somehow developed, and CrossFit, the kick-ass workout program I've been doing three times a week for the past seven months.

Other, more serious CrossFitters have told me how either the Zone or Paleo diets have helped them improve their performance in the various CrossFit skills. I could definitely stand to improve in all those skills.

An efficiently functioning digestive system will help me perform better in everyday life, and right now, that's just as high a priority as getting faster, stronger and leaner.

The Zone and Paleo diets seem like they would help me achieve both goals.

And it spreads........

Why I Love CrossFit

Something I found on line about why someone loves this shit....

Like 95% of females in this country, I have spent a really stupid number of hours of my life fretting about what number would show up when I stepped on a scale. But about eight years ago, when I decided to seek treatment for my food addiction, I started by buying two books, one called Overcoming Overeating and the other, When Women Stop Hating Their Bodies. In them, the authors said, Do NOT weigh yourself; throw out your scale. And I did. I didn’t weight myself for years. When I went to the doctor’s office, I would close my eyes and tell the nurse not to say my weight out loud. I still don’t weigh myself. I don’t own a scale. I only know approximately how much I weigh.

Here’s the thing, I like measurable results. I like to see data about how I’ve improved. Or not. I think it can be really motivational. But only when there’s no mental illness involved in your outcomes.

Because, for a compulsive overeater/food addict/emotional eater/what-have-you, the absolute worst thing you can do is focus on your weight. If you’re trying to heal yourself from obsessive thoughts about food, weighing yourself adds a whole new level of crazy. I know this first-hand. When I used to go on diets, I would think about nothing but food, I would gorge myself on food I hated because it was low in Points, and I would scheme how to trick the scale—”Maybe if I take off my earrings before I weigh in, I’ll hit my weight goal.”

Now I have a new weight goal. It’s called a PR, and I won’t ever see it by stepping on a scale. A PR is a personal record. As in, you pick up more weight than you ever have before.

You may remember my first attempts at the clean & jerk back in late August. I was lifting about 25 lbs. Well, by December 29, I hit a one-rep max of 73 lbs. I hadn’t tried for a new 1RM since. This week’s Open WOD called for clean & jerks…at 110 lbs. for females. Ha! I knew I wouldn’t be able to C&J 110 lbs., but I figured it was a good time to find my new 1RM. If I hit 88 pounds, I was fixing to be really happy.

I worked up to 73, doing three reps at a time. Cake.

I decided to do one rep at each increment from there on out.

78. Easy.

83. No problem.

88. Fine.

93. Fail.

Coaching from Rich…93. Yep.

95.5. With more coaching from Rich, done.

98. Rich, coaching, got it.

100.5. Fail. Rest. Rich, coaching. Cleaned, and motherfucking jerked.

I tried 103, but I was shot. I did not care. 100.5 pounds! Now I can’t wait to get back in there and lift 103 pounds over my head.

Why I love CrossFit (with a hat tip to friend and awesome athlete,Nell, and I quote): My “weight goal” is now something that I want to LIFT, as opposed to something I want to BE.

Inspiration from within our own walls

April 13, 2011 by Andrea  
Filed under Member Achievements, Why CrossFit

16 Comments

There are many CrossFit athletes and celebrities who can accomplish unfathomable feats, who give us a benchmark to chase and a jaw-dropping glimpse of how it’s supposed to be done.  But anyone who witnessed the competitive spirit inside FirePower during sectional competition WOD #3, amidst the deafening cheers with every single squat clean & jerk, or best-efforts to simply lift the bar off the ground, a life-changing moment was happening in our midst…

________________________________

To the FirePower Nation,

As a trainer, my job is pretty simple. Impart the knowledge necessary to complete the task, and inspire the individual to do so. But this past week, it was the opposite that happened.

In all of CrossFit the clean is bar-none my favourite movement. My work capacity doesn’t stretch far past five minutes, so this teeter-totter that was 11.3 was really tipping in my favour.

The problem was I couldn’t have cared less. My tires were flat. My A/C wasn’t working, and my muffler was making funny noises. I was burnt. The work-out that should’ve been mine was being whisked away at the hands of apathy and exhaustion.

On Wednesday morning, after ass-dialling the ex at 5:45 am, I came in ready to field complaints and concerns about Friday night. Instead what I got were ten or so athletes eager to dial in the cue’s they’d been punched in the face with since the day they first laid hands on a bar. My spark was lit.

The next day I started to contemplate my own performance. I accepted the fact that this workout would be my first after a week off, and as a result, negated the use any of my normal, tired excuses for putting on a less than stellar performance. Perfect! Just the spot I wanted to be in.

Pushing Limits of New Knees

Younger Patients Choose Surgery; Some Sports Are OK, But Which Are Too Much?

• By MELINDA BECK

John Jeffries, a 49-year-old money manager in Dover, Mass., had hip-resurfacing surgery in 2008 and is now coaching his son's basketball team and long-distance cycling.

Alex Douglas, a Wall Street software architect, had both knees replaced last year at 39 after years of sports injuries. He can't wait to go kite-boarding this weekend. "I've been cleared to have fun," he says.

Hard charging baby boomers and Generation X-ers are wearing out their joints at younger ages and turning to joint replacement surgery. But is it a quick fix? WSJ's health columnist Melinda Beck discusses with Kelsey Hubbard.

Joint-replacement patients these days are younger and more active than ever before. More than half of all hip-replacement surgeries performed this year are expected to be on people under 65, with the same percentage projected for knee replacements by 2016. The fastest-growing group is patients 46 to 64, according to the American Academy of Orthopaedic Surgery.

Many active middle-agers are wearing out their joints with marathons, triathlons, basketball and tennis and suffering osteoarthritis years earlier than previous generations. They're also determined to stay active for many more years and not let pain or disability make them sedentary.

To accommodate them, implant makers are working to build joints with longer-wearing materials, and surgeons are offering more options like partial knee replacements, hip resurfacing and minimally invasive procedures.

More younger people also need joint-replacement surgery due to obesity, and some orthopedists refer them for weight-loss surgery first to reduce complications later.

Even the most fit patients face a long period of rehabilitation after surgery and may not be able to resume high-impact activities.

ALBANY CROSSFIT PROMO

Watch more video of Best CrossFit Gyms on sicfit.com

Day 30... You did it!!!

Today is the final day of the Paleo challenge... I hope you learned a great deal on how food can effect you mood, performance, and overall well being... I also hope this got you kick started for that summer body you are striving for....


Remember, photos must be submitted by 7pm tonight...